TLR2 Arg753Gln Gene Polymorphism Associated with Tuberculosis Susceptibility: An Updated Meta-Analysis

Table 1

Individual characteristics of the studies included in this meta-analysis.

Author	Year	Sample types	Country	Ethnicity	Genotyping method	Sample size		HWE
						(case/control)
						case	control
Ogus-a [6]	2004	PTB	Turkey	Caucasian	PCR-RFLP	151	116	≤0.01
Ogus-b [6]	2004	EPTB	Turkey	Caucasian	PCR-RFLP	129	116	≤0.01
Jin [7]	2006	PTB	China	Asian	PCR-SSP	170	199	0.23
Ma-a [2]	2007	TB	African Americans	African	Sequencing	339	194	NA
Ma-b [2]	2007	TB	European American	Caucasian	Sequencing	180	110	0.81
Ma-c [2]	2007	TB	Hispanics	Mixed	Sequencing	375	114	0.85
Yu [8]	2008	TB	China	Asian	PCR-RFLP	77	75	NA
Biswas [9]	2009	PTB	India	Asian	PCR-RFLP	100	100	NA
Strapagiel [10]	2008	TB	Poland	Caucasian	PCR-RFLP	79	62	0.90
Xue [11]	2010	PTB	China	Asian	Sequencing	205	203	0.97
Selvaraj [12]	2010	PTB	Indian	Asian	PCR-RFLP	193	199	0.97
Ma [13]	2010	PTB	China	Asian	Sequencing	543	544	NA
Etokebe [14]	2010	PTB	Croatia	Caucasian	Taqman	103	105	0.96
Le [15]	2011	PTB	China	Asian	PCR-SSP	225	422	0.92
Dalgic-a [16]	2011	TB	Turkey	Caucasian	PCR-RFLP	138	200	0.61
Dalgic-b [16]	2011	PTB	Turkey	Caucasian	PCR-RFLP	60	200	0.1
Dalgic-c [16]	2011	EPTB	Turkey	Caucasian	PCR-RFLP	138	200	0.61
Sánchez [17]	2012	PTB	Columbia	Caucasian	MALDI-TOFMS	466	300	0.91
Torres-García [18]	2013	PTB	Mexican	Caucasian	Taqman	90	90	NA
Wu-a [19]	2015	TB	China	Asian	PCR-RFLP	225	422	0.92
Wu-b [19]	2015	PTB	China	Asian	PCR-RFLP	109	422	0.92
Salie [20]	2015	PTB	South African	African	NA	729	487	0.91
Jafari [21]	2015	PTB	Iranian	Asian	ARMS-PCR	96	122	0.93
Panwar-a [22]	2016	PTB	India	Asian	ARMS-PCR	106	106	NA
Panwar-b [22]	2016	PTB	India	Asian	ARMS-PCR	106	106	NA
Rizvi-a [23]	2016	EPTB	India	Asian	ARMS-PCR	130	130	NA
Rizvi-b [23]	2016	PTB	India	Asian	ARMS-PCR	130	130	NA
Saleh-a [24]	2017	PTB	Egypt	Mixed	PCR-RFLP	52	50	0.59
Saleh-b [24]	2017	EPTB	Egypt	Mixed	PCR-RFLP	44	50	0.59
Sun [25]	2017	PTB	China	Asian	SNaPshot	214	205	0.97
Mittal [26]	2018	PTB	Northern indian	Asian	PCR-RFLP	155	98	NA
Soeroto [27]	2018	PTB	Indonesian	Asian	PCR-RFLP	86	114	NA

PTB: pulmonary tuberculosis; EPTB: extra pulmonary tuberculosis; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; ARMS-PCR: amplification refraction mutation system-polymerase chain reaction; PCR-SSP (sequence specific primer); MALDI-TOFMS (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry); ARMS-PCR (the amplification refractory mutation system); HWE: Hardy-Weinberg equilibrium; SSCP, single strand conformation polymorphism; NA, not available.