Pentraxin 3 Detects Clinically Significant Fibrosis in Patients with Chronic Viral Hepatitis C

Table 3

PTX3 values for the detection of significant (F≥2), advanced (F≥3) fibrosis, and cirrhosis (F=4) in patients with chronic HCV.

	Cut-off values (ng/mL)	AUC (95%CI)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
F≥2	4.48	0.802; (0.727-0.877)	73.0	75.5	84.4	60.7
F≥3	5.23	0.867; (0.789-0.945 )	76.8	88.5	91.6	70.1
F=4	6.38	0.937; (0.895-0.979)	91.1	96.8	97.9	87.1

The optimal cut-off value was calculated from the ROC analysis for PTX3 and subsequently the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the PTX3 were calculated.