Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor- Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress

Figure 1

The concentration of hippocampal tumor necrosis factor-α (TNF-α) (a), interleukin 10 (IL-10) (b), brain-derived neurotrophic factor (BDNF) (c), and sirtuin-1 (SIRT-1) (d). Horizontal axis represents rats’ groups: Groups A (nonstressed-control), B (stressed-control) C (nonstressed + CA 300mg/kg/d), D (stressed + CA 150 mg/kg/d), E (stressed + CA 300 mg/kg/d), and F (stress + CA 600 mg/kg/d). ANOVA followed by Tukey post hoc test <0.05.

(a) TNF-α

(b) IL-10

(c) BDNF

(d) SIRT1