MiR-486-5p Suppresses Proliferation and Migration of Hepatocellular Carcinoma Cells through Downregulation of the E3 Ubiquitin Ligase CBL

<div>Overexpression of miR-486-5p inhibited the proliferation and migration of HCC cells. (a) Expression of miR-486-5p in normal liver cells (L-02) and HCC cell lines (HepG2, Huh-7, and SMMC-7721). (b) Expression of miR-486-5p in SMMC-7721 cells transfected with an overexpression vector compared with control SMMC-7721 cells. (c) CCK-8 assay showing reduced proliferation of SMMC-7721 HCC cells overexpressing miR-486-5p compared with control SMMC-7721 cells. (d) Wound-healing assay showing that miR-486-5p overexpression reduced the migratory capacity of SMMC-7721 cells. (e) Transwell assay confirming reduced migratory ability of SMMC-7721 HCC cells overexpressing miR-486-5p. 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BioMed Research International

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Figure 2

Figure 2: MiR-486-5p Suppresses Proliferation and Migration of Hepatocellular Carcinoma Cells through Downregulation of the E3 Ubiquitin Ligase CBL 