MiR-486-5p Suppresses Proliferation and Migration of Hepatocellular Carcinoma Cells through Downregulation of the E3 Ubiquitin Ligase CBL

<div>CBL is a downstream target of miR-486-5p. (a) Venn diagram constructed using four miRNA databases showing genes that may be regulated by miR-486-5p. (b) KEGG analysis of 22 potential targets of miR-486-5p. (c) GO analysis of these 22 potential targets of miR-486-5p. (d) Expression of these 22 target genes in control SMMC-7721 hepatoma cells and SMMC-7721 cells overexpressing miR-486-5p as measured by qPCR. (e) Expression of CBL in HCC cell lines, including SMMC-7721 cells overexpressing miR-486-5p, measured by western blot. 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BioMed Research International

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Figure 3

Figure 3: MiR-486-5p Suppresses Proliferation and Migration of Hepatocellular Carcinoma Cells through Downregulation of the E3 Ubiquitin Ligase CBL 