MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway

Figure 5

Effects of miR-21-3p expression and either AKT or CDK2 activity on FOXO1 level in TECs. (a, b) Representative Western-Blotting results of FOXO1, phosphate FOXO1 (p-FOXO1), and intranuclei FOXO1 (nuclei-FOXO1) expression levels in NRK52E cells with diverse treatments (AKT OEX P: AKT overexpression plasmid; CDK2 OEX P: CDK2 overexpression plasmid; : P<0.05 vs. Control; #: P<0.05 vs. miR-21-3p inhibitor group; : P<0.05 vs. miR-21-3p mimic group).

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