Effects of Hexane Root Extract of Ferula hermonis Boiss. on Human Breast and Colon Cancer Cells: An In Vitro and In Vivo Study

Figure 3

Effect of the FHRH extract on the mRNA expression of apoptosis-associated genes. Fold change of p53, Bax, and caspases 3, 8, 9 genes in MDA-MB-231 cancer cells treated with IC₅₀ concentrations (18.2 μg/ml) for 48 h. P<0.05, P<0.005, and P<0.0005 compared to the control cells (DMSO vehicle). Data are presented as the mean ± standard deviation in the three independent experiments carried out in triplicate.