Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia

Figure 1

Numerical predictive check (NPC) coverage plots for CZP and NCZP plasma concentrations. The plot shows the ratios between observed and expected percentages of data above the upper and below the lower limits of the 0%, 20%, 40%, 50%, 60%, 80%, 90%, and 95% prediction intervals (black dots), and their corresponding predicted distribution as 95% confidence intervals (blue area). Outliers are shown as red dots.

(a) Clozapine coverage NPC

(b) Norclozapine coverage NPC