| | | Molecules in Network | Score | Focus Molecules |
| | Cardiovascular Disease, Metabolic Disease, Lipid Metabolism | ACVR1B, C14ORF139, CD3, CD36, DDX58, DYX1C1, E2f, EFHC1, EPPK1, FST, GPAM, HAMP, HSPA1A, IFN Beta, IKK, INHBE, INSIG2, KLF3, MAP3K8, MAP3K13, NCF2, NF-κB (family), NFATC2, NFκB (complex), NR2F2, Rab11, RAB11B, RAB11FIP4, RGS3, SLC2A2, SQSTM1, TFRC, TMEM126B, TXNRD1, VSNL1 | 46 | 28 |
| | Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Morphology | ADM, AGPAT9, Akt, BHLHB2, DCBLD2, HELLS, HSPG2 (includes EG:3339), Ige, IGF2, IGF2BP2, IL11, INPP5D, JAG1, Laminin, LCAT, Mek, NEXN, p70 S6k, PALLD, Pdgf, PDGF BB, PP2A, Ptk, RORA, Shc, SKAP2, SLC2A3, SLC6A4, SLC6A6, SORBS2, Sos, STAT, Tgf beta, TINAG, XRN1 | 33 | 22 |
| | Endocrine System Disorders, Hematological Disease, Metabolic Disease | Adaptor protein 2, AKR1B10, Ap1, AP2A1, BNIP3L, C5ORF34, CBR1, Ck2, Creb, DENND4A, hCG, HIP1, Histone h3, HMOX1, Igfbp, IGFBP1, IGFBP3, JUN, KLF5, LDL, MAFF, MAZ, Mmp, NRP1, P38 MAPK, PFKFB3, SMC4, SPP1, SULT2A1, SYNE2, tyrosine kinase, VDR, Vegf, VitaminD3-VDR-RXR, VRK1 | 32 | 22 |
| | Cardiovascular System Development and Function, Tissue Morphology, Amino Acid Metabolism | A1CF, AKR1C1, AKR1C2, AKR1C3, Angiotensin II receptor type 1, EGR1, ERK, ETS, F2RL1, FGFR3, Fibrin, FOS, G-Actin, GCLC, GCLM, GDF15, GNRH, JUN/JUNB/JUND, KLB, KLF4, LIMA1, NF1, NGF, NTN4, PLAUR, Rar, RASGRF2, Rxr, SCLT1, SERPINE1, SWI-SNF, T3-TR-RXR, Thyroid hormone receptor, TRA2A, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 30 | 21 |
| | Cellular Assembly and Organization, Cellular Function and Maintenance, Nervous System Development and Function | 14-3-3, ACTA1, ALB, ARHGAP26, ARHGDIA, ATP6V0A1, ATYPICAL PROTEIN KINASE C, CCAR1, CPLX1, F Actin, F2RL2, FGD4, GABBR1, Gsk3, Insulin, Jnk, MAP2K1/2, MARCKS (includes EG:4082), NEDD4L, Nfat, PARD3, PCYT1B, Pkc(s), Pld, PRLR, Rac, Raf, Ras, Ras homolog, RGNEF, SH3BP2, SOS1, TCR, TNS1, VAMP2 | 26 | 20 |
| | Cellular Movement, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities | ADCY, AIM1 (includes EG:202), ALP, ARFGEF1, ARID1A, Calmodulin, Calpain, Cyclin A, Cyclin E, CYP1A1, ERK1/2, G alphai, Hdac, Histone h4, IL8, IL12, Interferon alpha, ITPR2, KNG1 (includes EG:3827), Mapk, MED13, MYLK, NDRG1, NRD1, PDZK1, Pka, Pkg, PRKAR1A, PTRF, Rb, RBL1, RNA polymerase II, SMARCA4, SUV420H1, THRB | 24 | 18 |
| | Cancer, Cell Death, Reproductive System Disease | AASS, ANXA3, APPBP2, beta-estradiol, BICD1, BUB1, CCAR1, CHM, CORO2A, DIMT1L, EID3, FCGRT, geranylgeranyl pyrophosphate, GJB2, GRM3, HELLS, HRAS, IGFBP1, IREB2, KIAA2018, KLHDC2, MIRN29B2, MYC, NME5, NR3C1, PDK1, PTP4A2, RAB6A, RABGGTB, RASA4 (includes EG:10156), RPN2, SARDH, SELENBP1, SGK3, TXN | 23 | 17 |
| | Cancer, Cell Cycle, Cell Death | ABAT, ADM, ALDH5A1, BMP15, CDKN2B, CEACAM5 (includes EG:1048), CENPE, CENPF, CMAS, CRK, FOXG1, FSH, FST, GCLC, GPRC5A, GRLF1, HNRPDL, INHA, KCNA5, KLF10, LACTB, LYVE1, MST1R, MTMR10, PCF11, PGRMC1, RB1, SEMA6B, SMAD5, SPAG4, TGFB1, THOC1, THOC2, thyroid hormone, TRIP11 | 21 | 16 |
| | Cell Death, Cancer, Cell Cycle | ACAP1, ADAM12, BBS7, C10ORF88, C16ORF57, C3ORF63, CALR, CD59, CLTC, CMIP, CUGBP1, DCP1A, F2RL2, KIAA1219, KIAA1429, KRT18, METTL7A, MME, PDIA2, PDIA3, PHACTR2, PPP1CA, PRLR, SH3BP4, SLC6A8, SMAD4, SRC, SSB, TFE3, TNS1, TOM1, TOM1L1, TUSC3, YWHAZ, ZFYVE16 | 21 | 16 |
| Cancer, Hepatic System Disease, Liver
Hyperplasia/Hyperproliferation | ATP5S, C3, CTBP1, CYP4B1, CYP4F11, EDA2R, ELK3, FGD4, FRY, GDF15, GPRC5A, LEFTY2, LRBA, MAP3K13, MAPK8, MAPK9, MINK1, MSLN, PEX1, PKP2, PRAM1, RAE1, RCOR3 (includes EG:55758), retinoic acid, RGL4, SH3BP5, SH3RF2, SMOX, SPAG9, SSBP3, STMN3, TAL1, TFF2, YWHAG, ZNF217 | 21 | 16 |
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