Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02

<p>Effects of proanthocyanidins (PC) on the contents of multidrug resistance-associated protein 1 (MRP1, ng/mg) in L-02 cells exposed by ATO. Values are means (n=3 for each group), with standard deviations represented by vertical bars. <svg height="11.8878pt" id="M56" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.838 7.01903 11.8878" width="7.01903pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M682 0V33C615 38 603 49 571 134C507 305 441 494 378 665L343 655L136 136C101 48 86 41 22 33V0H246V33C170 41 161 50 183 112C196 152 209 192 224 232H441C461 176 478 126 493 87C504 49 499 41 433 33V0H682ZM425 279H242C273 363 303 448 335 533H337L425 279Z"></path></g></svg> Indicating significant difference from the blank control group at P&lt;0.05. <svg height="11.8878pt" id="M57" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.838 6.05995 11.8878" width="6.05995pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M384 354C435 370 515 408 515 502C515 549 494 593 459 616C426 639 384 650 308 650H45V618C127 613 130 606 130 524V127C130 45 125 38 37 33V0H262C342 0 409 12 461 40C521 73 558 124 558 192C558 295 481 336 384 352V354ZM217 365V556C217 587 221 597 229 604C238 611 261 615 288 615C382 615 421 558 421 490C421 406 374 365 266 365H217ZM217 327H264C384 327 457 284 457 183C457 80 383 38 301 38C235 38 217 55 217 127V327Z"></path></g></svg> Indicating significant difference from ATO exposure group at P&lt;0.05. <svg height="11.8878pt" id="M58" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.838 6.745 11.8878" width="6.745pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M618 181C565 77 513 26 413 26C264 26 151 150 151 336C151 486 240 625 407 625C516 625 573 582 600 475L634 483C627 540 622 581 613 638C585 643 518 665 435 665C211 665 46 526 46 315C46 158 157 -15 406 -15C480 -15 564 4 594 12C612 43 638 121 651 168L618 181Z"></path></g></svg> Indicating significant difference from PC(10mg/L)-treated group at P&lt;0.05. <svg height="11.8878pt" id="M59" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.838 7.39352 11.8878" width="7.39352pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M43 650V617C122 612 130 606 130 522V128C130 44 122 37 34 32V0H275C400 0 497 25 573 82C652 142 698 229 698 350C698 445 662 518 613 565C549 625 456 650 327 650H43ZM217 544C217 580 220 591 229 599C240 607 264 613 311 613C380 613 437 599 482 570C561 523 598 436 598 336C598 177 511 40 324 40C248 40 217 61 217 135V544Z"></path></g></svg> Indicating significant difference from PC(25mg/L)-treated group at P&lt;0.05.</p>

BioMed Research International

fig7

Figure 7

Figure 7: Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02 