Inhibition of LOXL2 Enhances the Radiosensitivity of Castration-Resistant Prostate Cancer Cells Associated with the Reversal of the EMT Process

Figure 1

LOXL2 was upregulated in CRPC cell lines and radioresistant prostate cancer samples. (a) Diagrammatic representation of heatmap of DEGs in the TCGA dataset. (b) LOXL2 expression was significantly higher in samples of the radioresistant group (RR) than in the radiosensitive group (RS) from the TCGA dataset. (c) Diagrammatic representation of heatmap of DEGs in prostate cell lines with different androgen dependency status from the GEO dataset. (d) A captured histogram picture from the GEO dataset, which shows that the expression of LOXL2 was upregulated in androgen-independent prostate cell lines. (e) LOXL2 expression was higher in CRPC cells of DU145 and PC3 cells than in androgen-dependent LNCaP and 22Rv1 cells at the mRNA level measured by real-time PCR. (f) LOXL2 expression was higher in DU145 and PC3 cells than in LNCaP and 22Rv1 cells at the protein level. denotes p <0.05 by Student's t-test.

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