Investigation of Interaction between Vitamin D Receptor Gene Polymorphisms and Environmental Factors in Early Childhood Caries in Chinese Children
Table 3
Allele and genotype frequencies of five VDR gene polymorphisms of the participants.
Caries-free group (n = 245)
Moderate caries risk group (n = 156)
High caries risk group (n = 148)
CdX-2
A
198 (40.4)
138 (44.2)
125 (42.5)
1.177
0.555
G
292 (59.6)
174 (55.8)
169 (57.5)
AA/AG/GG
37/124/84 (15.1/50.6/34.3)
28/82/46 (17.9/52.6/29.5)
31/63/53 (21.1/42.9/36.1)
4.648
0.325
Carriage of allele A
161 (65.7)
110 (70.5)
94 (63.9)
1.626
0.444
Fok I
C
269 (54.9)
166 (53.2)
190 (64.2)
8.952
0.011
T
221 (45.1)
146 (46.8)
106 (35.8)
CC/CT/TT
75/119/51 (30.6/48.6/20.8)
40/86/30 (25.6/55.1/19.2)
58/74/16 (39.2/50.0/10.8)
10.899
0.028
Carriage of allele C
194 (79.2)
126 (80.8)
132 (89.2)
6.715
0.035
Carriage of allele T
170 (69.4)
90 (60.8)
116 (74.4)
6.625
0.036
Taq I
C
39 (8.0)
14 (4.5)
17 (5.7)
4.191
0.123
T
449 (92.0)
298 (95.5)
279 (94.3)
CC/TT/TC
1/37/206 (0.4/15.2/84.4)#
0/14/142 (0.0/9.0/91.0)
1/15/132 (0.7/10.1/89.2)
—
0.197
Carriage of allele C
38 (15.6)
14 (9.0)
16 (10.8)
4.289
0.117
Bsm I
A
33 (6.7)
12 (3.8)
16 (5.4)
3.049
0.218
G
457 (93.3)
300 (96.2)
280 (94.6)
AA/AG/GG
1/31/213 (0.4/12.7/86.9)
0/12/144 (0.0/7.7/92.3)
0/16/132 (0.0/10.8/89.2)
—
0.401
Carriage of allele A
32 (13.1)
12 (7.7)
16 (10.8)
2.825
0.244
Apa I
A
142 (29.1)
78 (25.2)
85 (28.7)
1.603
0.449
C
346 (70.9)
232 (74.8)
211 (71.3)
AA/AC/CC
21/100/123 (8.6/41.0/50.4)#
9/60/86 (5.8/38.7/55.5)
8/69/71 (5.4/46.6/48.0)
3.864
0.425
Carriage of allele A
121 (49.6)
69 (44.5)
77 (52.0)
1.816
0.403
When cells had expected count <5, Fisher’s exact test was used. Using MGB-TaqMan® genotyping method, 1 subject in the high caries risk group had negative result of Cdx-2. 1 subject in the caries free group had negative result of Taq I. 1 subject in the caries-free group and 1 subject in the moderate caries risk group had negative result of Apa I.
