MiR-221 Promotes Hepatocellular Carcinoma Cells Migration via Targeting PHF2
Figure 1
miR-221 is upregulated in HCC tissues and cell lines and promotes the cell migration. (a) qRT-PCR results of miR-221 mRNA levels in HCC cell lines and human normal hepatocyte. (b) Quantitative PCR results of miR-221 mRNA levels in HCC tissues (T) and in adjacent noncancerous tissues (N). MiR-221 mRNA levels are higher in the HCC tissues (T) than in adjacent noncancerous tissues (N) (n=12). (c) miR-221 increases SMMC-7721 cells wound healing. Anti-miR-221 inhibits SMMC-7721 cells wound healing. Lines indicate the border of the healing wounds. (d) The cell migration of SMMC-7721 cells after transfection with miR-221 or anti-miR-221 and their negative control detected by transwell assays. Each bar represents the mean ± SD of three independent experiments. P<0.01.