MiR-221 Promotes Hepatocellular Carcinoma Cells Migration via Targeting PHF2
Figure 4
PHF2 is decreased in hepatocellular carcinoma tissues and associated with clinicopathological features in 60 hepatocellular cancer patients. (a) Representative photos of PHF2 expression patterns in hepatocellular tumors. The left panel depicts matched adjacent cancer tissues, whereas the right panel represents the hepatocellular carcinoma tissues (original magnification, ×100). The magnifying detail of the immunohistochemical analysis for each case can be shown in the bottom side (original magnification, ×200). (b) Compared with the adjacent cancer tissues, the overall expression level of PHF2 in the hepatocellular carcinoma tissues was significantly lower, P<0.05, χ2 test. PHF2 expression was correlated with TNM stage, P<0.05, χ2 test. (c) Kaplan-Meier estimates of the probability of 3-year overall survival according to low and high PHF2 expression of 60 patients with hepatocellular cancer. P=0.0437, log-rank test. (d) The correlation between the protein expression of miR-221 and PHF2 was measured by Pearson's correlation coefficient analysis.