Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially

Figure 4

Nontargeted serum metabolomics and expression levels of hepatic iNOS and FXR. (a, b) Partial least-squares discriminant analysis of significantly different negative ions and positive ions. (c, d) Heat maps of significantly different negative ion and positive ion clustering. (e) The number of significantly different negative ions and positive ions in the GI group compared with the GH group. (f) Comparison of liver iNOS and FXR expression levels. p<0.05; p<0.01.

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