Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially

Figure 6

Alteration of the liver and microbiome after BBR intervention. (a) HE and immunohistochemical staining of the liver, score of the hepatic sinusoid expression, and number of KCs with hyperplasia. (b) The altered composition of the fecal microbiome at the genus level after BBR treatment. Quantification of fecal SCFAs (c) and fecal LPS (d). (e) Protein expression levels of hepatic iNOS and FXR. p<0.05; p<0.01.

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