Shuangyu Tiaozhi Granule Attenuates Hypercholesterolemia through the Reduction of Cholesterol Synthesis in Rat Fed a High Cholesterol Diet

Figure 5

Different treatment times of STG on protein expression of HMGCR and SREBP-2 in rat fed a HC diet. (a-b) Western blotting was performed to detect HMGCR and SREBP-2 protein levels in rat treated by high or low dose of STG for 4 or 8 weeks. P < 0.05, P < 0.01 versus control group; P < 0.05, P < 0.01 versus HC group; P < 0.01 versus STG treatment for 4 weeks. SREBP-2 (N), nuclear SREBP-2. (c) The expression of SREBP-2 in rat liver tissue was detected by immunohistochemistry after STG treatment for 4 or 8 weeks. All data were shown as mean ± SD.

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