Shuangyu Tiaozhi Granule Attenuates Hypercholesterolemia through the Reduction of Cholesterol Synthesis in Rat Fed a High Cholesterol Diet

Figure 7

Schematic diagram of molecular mechanisms of Shuangyu Tiaozhi Granule (STG) attenuates hypercholesterolemia in rat fed HC diet. STG reduces contents of plasma cholesterol through the inhibition of cholesterol synthesis pathway and promotion of hepatic cholesterol uptake. STG treatment downregulated HMGCR and SREBP-2 expression and increased LDLR levels, whereas circulating LDL-C was uptake from plasma. HMGCR, 3-hydrox-3-methylglutaryl-CoA reductase; LDLR, low-density lipoprotein receptor; SREBP-2, sterol regulatory element-binding protein-2; ACAT-2, acyl coenzyme A-cholesterol acyltransferase-2; CYP7A1, cholesterol 7-α-hydroxylase; ABCG5, ATP-binding cassette transporter G5; ABCG8, ATP-binding cassette transporter G8; (+) promotion, (-) inhibition, ↑ represents upregulation, ↓ represents downregulation.