Molecular Modelling and Dynamics Study of nsSNP in STXBP1 Gene in Early Infantile Epileptic Encephalopathy Disease

Figure 3

Example of the comparison of the native STXBP1 protein structure and its mutant forms. S42 (wild type-STXBP1) and 42P (variant protein), R190 (wild type-STXBP1) and 190 W (variant protein), D238 (wild type-STXBP1) and 238E (variant protein) and P335 (wild type-STXBP1) and 335S (variant protein). Residues substituted are showed in red, residues involved in hydrogen bonds are marked in cyan, residues participate in hydrophobic interactions are indicated in magenta, residues participate in both hydrogen bonds and hydrophobic interactions are marked in orange, and the residues which lost a hydrogen bonds and/or hydrophobic interactions are marked in blue, and the new residues appeared are indicated in green. Hydrogen bonding is marked by yellow dashed lines and hydrophobic interactions are shown by green lines.