Review Article
Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
Table 1
Selected characteristics of 18 studies in review of leucocyte telomere length and CHD.
| | P/R studies | Major investigators | NOS | Mean TL in CHD(SD) | CHD cases | Mean TL in Control (SD) | Control case | Location | Year | Ethnicity | Population source | Mean age (SD) | Men (%) | Total cases | Assay method | CHD definition | TL units |
| | Prospective studies | Zee RY | 8 | 3.41(0.63) | 337 | 3.52(0.78) | 337 | US | 2009 | white American | Occupational list | 60(9) | 100 | 674 | qPCR | mixed | loge T/S |
| | Prospective studies | Ida Beate | 8 | 0.29(0.11) | 82 | 0.24(0.12) | 833 | Norway | 2017 | Norwegian | Population based cohort | 71(5) | 48 | 915 | qPCR | mixed | T/S |
| | Prospective studies | Nordfjallk | 7 | 0.65(0.19) | 226 | 0.65(0.20) | 444 | Sweden | 2007 | Swede | Population based cohort | 61(5) | 69 | 670 | qPCR | mixed | T/S |
| | Prospective studies | Njajou OT | 7 | 4.80(1.30) | 189 | 4.90(1.20) | 2721 | US | 2009 | African American and white American | Insurance register and area code residence | 74(3) | 49 | 2910 | qPCR | fatal | kb |
| | Retrospective studies | Cui G | 7 | -0.20(0.45) | 2140 | -0.03(0.51) | 2211 | China | 2014 | Chinese | Hospital patients/community sample | 59(9) | 54 | 4351 | qPCR | non-fatal | loge T/S |
| | Retrospective studies | Zhang | 7 | 5.19(0.53) | 52 | 6.24(2.54) | 42 | china | 2016 | Chinese | Hospital patients/volunteers | 49(9) | 60 | 94 | qPCR | mixed | kb |
| | Prospective studies | Masi | 7 | 0.92(0.18) | 61 | 0.98(0.21) | 428 | UK | 2016 | British | Hospital patients/volunteers | 67(27,91) | 62 | 489 | qPCR | mixed | T/S |
| | Prospective studies | Benetos A | 7 | 6.42(0.84) | 259 | 6.69(0.68) | 79 | France | 2017 | French, Athenian | Hospital patients/volunteers | 63(14) | 68 | 338 | Southern blotting | mixed | kb |
| | Retrospective studies | Tian R | 7 | 4.97(1.37) | 128 | 5.32(0.91) | 128 | China | 2017 | Chinese | Hospital patients/volunteers | 49(7) | 74 | 256 | qPCR | mixed | kb |
| | Retrospective studies | Maubaret | 6 | 7.85(4.01) | 520 | 8.04(4.46) | 559 | Multiple | 2010 | European | Hospital patients/community sample | 52(6) | 100 | 1079 | qPCR | non-fatal | loge T/S |
| | Retrospective studies | Russo A | 6 | 0.77(0.19) | 199 | 0.76(0.19) | 190 | Italy | 2012 | Italian | Hospital patients/unspecified | 40(5) | 90 | 389 | qPCR | non-fatal | T/S |
| | Retrospective studies | Brouilette S | 5 | 6.75(0.18) | 203 | 7.05(0.15) | 180 | UK | 2003 | British | Hospital register/GP register | 47(6) | 86 | 383 | Southern blotting | non-fatal | kb |
| | Retrospective studies | Starr JM | 5 | 5.67(2.14) | 38 | 6.96(1.72) | 190 | UK | 2007 | British | Population based cohort | 79(0) | 82 | 228 | qPCR | non-fatal | kb |
| | Retrospective studies | Mukherjee | 5 | 1.18(0.45) | 76 | 1.34(0.44) | 238 | India | 2009 | Indian | Hospital patients/community sample | 57(11) | 78 | 314 | qPCR | non-fatal | T/S |
| | Retrospective studies | panweiwei | 5 | 0.87(0.31) | 80 | 1.12(0.25) | 76 | china | 2014 | Chinese | Hospital patients | 58(4) | 53 | 156 | qPCR | mixed | T/S |
| | Retrospective studies | Liulong | 4 | 4.21(0.33) | 30 | 7.98(0.54) | 30 | China | 2015 | Chinese | Hospital patients/volunteers | 47(6) | 67 | 60 | Southern blotting | mixed | kb |
| | Prospective studies | Dlouha | 4 | 0.86(0.32) | 505 | 0.93(0.38) | 642 | Czech | 2015 | Czech | Insurance register/Hospital patients | 60(7) | 0 | 1147 | qPCR | mixed | T/S |
| | Retrospective studies | Spyridopoulos I | 3 | 6.54(0.55) | 25 | 6.96(0.86) | 13 | Germany | 2009 | German | Hospital patients/volunteers | 65(2) | 100 | 38 | FISH | non-fatal | kb |
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CHD: coronary heart disease; FISH: flow cytometry-fluorescent in situ hybridization; NOS: Newcastle-Ottawa scale; qPCR: quantitative polymerase chain reaction.
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