Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis

Figure 1

Gross specimen of the liver assessed by HE staining and transmission electron microscopy: (a) liver fibrosis specimens show that the liver surface and edge are not smooth; (b) hematoxylin-eosin (×100) and fibrous septa are formed; (c) transmission electron microscopy (×12000) shows thickening of the fibrous tissue septa, and deposition of the collagen fibers; (d) transmission electron microscopy (×12000) shows a decreased number of fenestrations of liver sinusoidal endothelial cells, and incomplete basement membrane formation was observed subcutaneously, which occurred during the hepatic sinus capillarization.

(a)

(b)

(c)

(d)