Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid

Figure 4

Representative histological findings of osteonecrosis, inflammation and femur defect healing. (a) Bone sequestra found in ZA-treated mandible. (b) Soft tissue inflammation found in ZA-treated mandible. Scale bar = 200 µm. (c) Femur of long-term control group, formation of cortical bridge at defect site. (d) Femur of long-term ZA group, spongy bone without maturation into cortical bone in defect site. Scale bar = 500 µm. NB: necrotic bone; CT: connect tissue; IF: inflammatory infiltration; EP: epithelium; LB: lamellar bone; WB: woven bone.

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