Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid

Table 2

Effect of zoledronic acid on bone mineral density (mean ± SD) in femur defect, and mandibular/maxillary extraction socket.

BMD (g/cm^3)^∗	2 wk	4 wk	8 wk
Femur
ZA	0.32 ± 0.09	0.57 ± 0.18	0.79 ± 0.06^∗
Control	0.35 ± 0.16	0.54 ± 0.06	0.68 ± 0.06
Mandible
ZA	0.84 ± 0.05	0.83 ± 0.09	0.93 ± 0.05^∗∗
Control	0.72 ± 0.07	0.81 ± 0.07	0.85 ± 0.03
Maxilla
ZA	0.75 ± 0.05	0.84 ± 0.03	0.91 ± 0.08
Control	0.67 ± 0.09	0.84 ± 0.13	0.93 ± 0.07

^∗Differences were considered significant at , ^∗, ^∗∗.