Research Article

Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid

Table 4

Histological assessment of fraction of empty lacunae out of viable lacunae.

Empty/viableShort-termMedium-termLong-term

Femur
ZA0.09 ± 0.080.08 ± 0.090.14 ± 0.07
Control0.18 ± 0.290.04 ± 0.030.08 ± 0.06
Mandible
ZA0.52 ± 0.660.22 ± 0.260.30 ± 0.57
Control0.10 ± 0.120.04 ± 0.030.06 ± 0.06
Maxilla
ZA0.28 ± 0.380.12 ± 0.07∗∗∗0.23 ± 0.26∗∗∗
Control0.10 ± 0.110.02 ± 0.020.03 ± 0.03

Differences were considered significant at , , ∗∗∗.