The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways

Table 2

Effect of AC on body weight and fasting blood glucose in each group (±SE, g, mmol/L).

Weeks	NC		DN		DN+M		DN+AC
	BW (g)	FBG (mM)	BW (g)	FBG (mM)	BW (g)	FBG (mM)	BW (g)	FBG (mM)
0 W	16.87±0.46	4.26±0.22	30.46±1.63	9.34±0.98	30.61±0.83	8.39±0.33	30.64±1.42	8.18±0.78
2 W	20.89±0.39	4.85±0.13	35.33±2.24	12.77±1.15	33.02±1.06	10.91±0.99	33.53±1.60	10.04±1.04
4 W	21.28±0.31	5.24±0.42	38.56±2.02	14.02±1.94	34.67±1.52	12.15±1.48	35.35±1.66	9.92±1.15
6 W	23.45±0.45	5.34±0.15	41.50±2.24	15.26±1.78	37.39±1.49	12.27±1.54	38.16±1.44	10.53±1.28
8 W	23.83±0.50	7.13±0.42	44.57±1.24	17.16±1.96	38.10±1.72	12.82±1.64	40.45±1.64	11.13±1.31#
10 W	24.55±0.40	7.20±0.50	46.38±1.85	19.02±2.00	39.73±1.95	14.59±2.00	41.06±1.85	13.88±1.60

Note: NC: normal control mice, DN: diabetic nephropathy mice, DN+M: DN mice given 180 mg/kg metformin, and DN+AC: DN mice given 300 mg/kg AC. BW: body weight and FBG: basting blood glucose.  : P<0.05 compared with the NC group; #: P<0.05 compared with the DN group.