The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways

Table 4

Effect of AC on 24 h urine volume and 24 h urinary albumin excretion in each group (±SE).

Weeks	NC		DN		DN+M		DN+AC
	24 h UV (ml/24 h)	24 h UAE (μg/24 h)	24 h UV (ml/24 h)	24 h UAE (μg/24 h)	24 h UV (ml/24 h)	24 h UAE (μg/24 h)	24 h UV (ml/24 h)	24 h UAE (μg/24 h)
2 W	4.07±0.51	1.48±0.14	14.06±1.76	4.60±0.56	12.25±2.14	3.97±0.66	12.35±1.42	4.67±0.68
4 W	4.85±0.21	1.94±0.10	20.57±3.06	5.25±0.55	13.57±1.98	4.49±0.58	15.64±2.03	4.57±0.36
6 W	5.14±0.30	1.54±0.11	23.50±3.18	5.80±0.81	18.35±2.17	4.61±0.37	17.56±1.17	4.31±0.21
8 W	4.93±0.43	1.34±0.07	26.00±2.92	6.39±0.63	18.28±2.27	4.28±0.48	17.06±1.50	3.78±0.41

Note: NC: normal control mice, DN: diabetic nephropathy mice, DN+M: DN mice given 180 mg/kg metformin, and DN+AC: DN mice given 300 mg/kg AC. 24 h UV: 24 h urine volume and 24 h UAE: 24 h urinary albumin excretion. : P<0.05 compared with the NC group; #: P<0.05 compared with the DN group.