Toll-Like Receptors as Therapeutic Targets in Central Nervous System Tumors

Figure 1

Summary mechanisms of TLR agonists as immunotherapy for CNS tumors. Activation of TLRs induces cytokine production, active NKs, dendritic cells, macrophage, T cell, and tumor cell apoptosis. TLR agonists can have local effect (A) and can also have a systemic effect (B).