Consequence of Two Protocols of Social Defeat Stress on Nicotine-Induced Psychomotor Effects in Mice

Figure 3

Locomotor activity in response to saline and nicotine (0.1 and 0.4 mg/kg, s.c.) challenges, in mice previously exposed to 13-day treatment with different nicotine doses (0.1, 0.4, or 1.0 mg/kg, daily). Short-term challenges were carried out within 2, 4 and 6 days after the end of the intermittent treatment, while long-term nicotine challenge was carried out 17 days after the last short-term challenge. Different from the control group on the same challenge day; #within-group difference relative to the saline challenge. In all cases, p<0.05.