HOTTIP Functions as a Key Candidate Biomarker in Head and Neck Squamous Cell Carcinoma by Integrated Bioinformatic Analysis

Figure 1

The HNSCC-specific lncRNA–miRNA–mRNA ceRNA network. (a) Construction of the HNSCC-specific lncRNA–miRNA–mRNA ceRNA network. Green circles: downregulated mRNAs; red circles: upregulated mRNAs; green hexagons: downregulated lncRNAs; red hexagons: upregulated lncRNAs; green squares: downregulated miRNAs; red squares: upregulated mRNAs. Grey lines denote lncRNA–miRNA and miRNA–target gene interactions. (b) Nodes with the highest degrees of connectivity in the ceRNA network. (c) Enriched pathways and functions of target genes in the ceRNA network by GO analysis.

(a)

(b)

(c)