Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis

<div>HIF1A upregulates GATA1 to promote the expression of HMGN5. (a) The expression levels of HIF1A mRNA were higher in HIF1AOE-GFP and HIF1AOE-GATA1sh groups than in the Cherry-GFP group. (b) The expression level of GATA1 mRNA in the HIF1AOE-GFP group was significantly higher than in the Cherry-GFP group and was knocked down in the HIF1AOE-GATA1sh group. (c) The expression level of HMGN5 mRNA in the HIF1AOE-GFP group was significantly higher than in the Cherry-GFP group, and the expression level of HMGN5 mRNA in HIF1AOE-GATA1sh group was significantly lower than in the HIF1AOE-GFP group. (d) GATA1 and HMGN5 had higher expression levels in the HIF1AOE-GFP group (compared with Cherry-GFP group) but lower expression in the HIF1AOE-GATA1sh group (compared with HIF1AOE-GFP group). 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BioMed Research International

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Figure 4

Figure 4: Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis 