L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells

Figure 4

L-Carnitine (L-C) effect on intracellular signaling in hOBs. (a): Representative Western blot of ERKs and AKT activation in hOBs after 5 and 15 min of treatment with 5 mM L-C. (b): Relevant quantification of ERK1/2 and AKT phosphorylation. L-C induced a significant phosphorylation of ERK1/2 at 15 min and of AKT at 5 and 15 min. Data are the mean ± SD of six experiments performed with cells obtained from different donors. Student’s t test: <0.05, <0.01,and <0.001 vs control (ctrl).

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