A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned Medium/Chitosan/Collagen/β-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice

Figure 3

The application of MSC-CM/hydrogel suppresses wound inflammation and facilitates reepithelialization in a mouse model of third-degree burns. (a) H&E stained images of wounded skin from the four groups on day 4: UM (unconditioned medium) group (I, II), MSC-CM group (III, IV), UM/hydrogel group (V, VI), and MSC-CM/hydrogel group (VII, VIII). Black dotted lines in I, III, V, and VII indicate epithelial tongue lengths. Bars in I, III, V, and VII represent 200 μm and those in II, IV, VI, and VIII represent 50 μm. Statistical analyses of inflammatory infiltration thickness (b), inflammatory cell density (c), and length of the epithelial tongue (d) on day 4 of wound healing. The asterisk () indicates between the compared groups.

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