P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin

Figure 1

Effects of different drugs on cells. , compared with control group; , compared with OXA group; , compared with RT group; , compared with combination of OXA and RT. Control: SGC-7901/NGEC; SB203580 : 15 nM; RT: 300 μM; OXA:33 μM; RT + OXA: (300 μM + 33 μM); RT + SB203580 (300 μM + 15 nM); RT + OXA + SB203580: (300 μM + 33 μM+15 nM). (a, b) Effect of different concentrations of RT and OXA on the toxicity of NGEC cells and the viability of SGC-7901 cells by MTT (, n = 6). (c) Effects of p38 inhibitor, RT, OXA, and drug combination on SGC-7901 cells proliferation assessed by MTT ( ± S, n = 6). (d) Morphological observation of SGC-7901 cells (Hoechst33258, ×200).

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