PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-α

Figure 2

PTEN mRNA were reduced and inflammatory factor mRNA was increased by ligature. (a) Quantitative real-time PCR analysis of PTEN mRNA transcripts from ligature-induced and control mice. Each sample was standardized to GAPDH levels and run in triplicate. Data represent PTEN expression in periodontal tissue relative to control. n = 5 biological replicates. Inflammatory factors (b) IL1, (c) IL6, and (d) TNF-α were measured as described in Materials and Methods from periodontal tissues. n = 5 biological replicates. Values are the mean ± SEM. ; ; n = 5 biological replicates.

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