Research Article
Chemokine Receptor CXCR3 Correlates with Decreased M2 Macrophage Infiltration and Favorable Prognosis in Gastric Cancer
Table 3
Correlation analysis of the expression of CXCR3 with M2 macrophage infiltration and the clinicopathologic parameters.
| | | High-CXCR3 expression | Low-CXCR3 expression | P value | | (n = 59) | (n = 97) |
| | CD163 | | | 0.001 | | High | 22 (37.29%) | 62 (63.92%) | | | Low | 37 (62.71%) | 35 (36.08%) | | | Gender | | | 0.483 | | Male | 45 (76.27%) | 69 (71.13%) | | | Female | 14 (23.73%) | 28 (28.87%) | | | Age | | | 0.303 | | < 58 | 33 (55.93%) | 46 (47.42%) | | | ≧58 | 26 (44.07%) | 51 (52.58%) | | | Diameter (cm) | | | 0.248 | | < 5 | 33 (55.93%) | 45 (46.39%) | | | ≧5 | 26 (44.07%) | 52 (53.61%) | | | Ki67 | | | 0.173 | | <10% | 9 (15.25%) | 8 (8.25%) | | | ≧10% | 50 (84.75%) | 89 (91.75%) | | | Lymph node metastasis | | | 0.143 | | No | 19 (32.20%) | 21 (21.65%) | | | Yes | 40 (67.80%) | 76 (78.35%) | | | Differentiation | | | 0.017 | | Well-moderately | 21 (35.59%) | 18 (18.56%) | | | Poorly | 38 (64.41%) | 79 (81.44%) | | | Invasion depth | | | 0.003 | | T1/T2 | 15 (65.22%) | 8 (34.78%) | | | T3/T4 | 44 (33.08%) | 89 (66.92%) | | | TNM stage | | | 0.02 | | I+II | 23 (38.98%) | 21 (21.65%) | | | III+IV | 36 (61.02%) | 76 (78.35%) | | | Lauren’s classification | | | 0.716 | | Intestinal | 25 (42.37%) | 44 (45.36%) | | | Diffuse | 34 (57.63%) | 53 (54.64%) | |
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T1, tumor invades lamina propria, muscularis mucosae, or submucosa; T2, tumor invasion of the muscularis propria; T3, tumor invasion subserosal connective tissue; T4, tumor invasion serosal or adjacent structures.
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