Chemokine Receptor CXCR3 Correlates with Decreased M2 Macrophage Infiltration and Favorable Prognosis in Gastric Cancer

Table 4

Univariate and multivariate analyses of predictive factors for the overall survival in GC patients.

	n	Univariate		Multivariate
		P-value	Hazard ratio, 95% CI	P-value	Hazard ratio, 95% CI
CXCR3 expression		0.001	0.306 (0.184-0.51)	0.001	0.342 (0.204-0.571)
High	59
Low	97
M2 macrophage		0.024	1.633 (1.068-2.589)
High	84
Low	72
Age		0.093	1.447 (0.94-2.27)
<58	79
≥58	77
Lauren’s classification		0.223	1.309 (0.848-2.021)
Intestinal	69
Diffuse	87
Diameter (cm)		0.96	1.011 (0.658-1.554)
<5	78
≥5	78
Invasion depth		0.004	3.111 (1.429-6.733)	0.024	2.482 (1.130-5.449)
T1/T2	23
T3/T4	133
TNM stage		0.005	2.113 (1.251-3.569)
I+II	44
III+IV	112
Lymph node metastasis		0.104	1.530 (0.917-2.553)
No	40
Yes	106
Differentiation		0.151	1.455 (0.872-2.428)
Well-moderately	39
Poorly	117