Adipokine Chemerin Stimulates Progression of Atherosclerosis in ApoE^−/− Mice

Figure 1

The circulating and aortic levels of chemerin increased in the progression of aortic atherosclerosis in ApoE^−/− mice. (a) The aortic morphology staining by HE, oil red O, and immunofluorescence assay for chemerin at different stages (0, 4, 8, 12, and 16 W) in ApoE^−/− mice fed with high-fat diet. (b), (c), and (d) The ratios of aortic neointima/media thickness, aortic plaque areas, and lipid percentages of aortic tissue at different stages. (e) Serum levels of chemerin investigated by ELISA at different stages. (f) The expression of chemerin in aortic tissues investigated by immunofluorescence assay at different stages. (g) Correlation analysis between aortic chemerin level and the ratio of aortic intima/media thickness. Scale bar: 0.1 mm. , compared with 0 W.

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