Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls

Table 3

Concentrations of metalloproteinases MMP-2, MMP-8, and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in UWS of JIA children and controls (C) including mixed and permanent dentition.

Salivary parameters		Total			Mixed dentition			Permanent dentition
		JIA; N = 34	C; N = 34	value	JIA; N = 15	C; N = 15	value	JIA; N = 19	C; N = 19	value
MMP-2	Mean (SD)	1.18 (1.82)	0.81 (1.06)	0.54	1.5 (2.23)	0.95 (1.32)	0.41	0.93 (1.43)	0.71 (0.82)	0.83
	Min-max	0–8.62	0–4.78		0–8.62	0–4.77		0–5.54	0–3.68
MMP-8	Mean (SD)	237.95 (224.17)	198.31 (160.53)	0.73	210.07 (164.68)	172.68 (164.04)	0.21	259.97 (264.34)	218.55 (159.16)	0.76
	Min-max	40.8–908	49.6–752		48.32–590	49.6–576		40.8–908	57.92–752
MMP-9	Mean (SD)	180.63 (200.69)	85.3 (143.3)	0.005	151.85 (147.42)	64.78 (84.77)	0.038	203.34 (236.01)	101.5 (177.28)	0.07
	Min-max	0–960	0–628.6		0–603.8	0–253.48		0–960	0–628.6
TIMP-1	Mean (SD)	266.1 (185.17)	211.09 (169.81)	0.227	256.98 (194.36)	220.52 (184.49)	0.68	273.31 (182.64)	203.65 (162.04)	0.3
	Min-max	0–667	0–737		38.5–667	15.5–737		0–609.1	0–527.2
TIMP-2	Mean (SD)	21.08 (12.1)	23.07 (15.61)	0.77	20.71 (10.95)	26.2 (20.89)	0.74	21.38 (13.23)	20.6 (9.63)	0.87
	Min-max	3.87–50.58	8.41–76.12		7.5–47.3	8.41–76.12		3.87–50.58	10.55–48.76

Note. Mann–Whitney test; statistically significant.