The Mycobacterium tuberculosis CRISPR-Associated Cas1 Involves Persistence and Tolerance to Anti-Tubercular Drugs

Figure 3

Cas1 recombinant M. smegmatis are hypersensitive to environmental stresses. Recombinant strains mc² 155_Cas1 and mc² 155_Vec were treated with (a) 5 mM H₂O₂ and (b) acidic MB 7H9 (pH 2.5) for indicated times. Error bars indicate standard deviation of triplicate experiments. P<0.05; P<0.01.

(a)

(b)