Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head

Table 1

miRNAs expression profiles in steroid-induced ONFH.

No.	Evaluation method	Sample	Dysregulation (up)	Dysregulation (down)	References
1	qRT-PCR	Human BMSCs	—	hsa-miR-122-3p	[10]
2	qRT-PCR	Human and rat ONFH tissue and serum	miR-1207-5p	—	[11]
3	Microarray qRT-PCR	Rat BMECs	2 miRNAs; miR-132-3p, miR-335	2 miRNAs; miR-466b-2-3p, let-7c-1-3p	[12]
4	Microarray qRT-PCR	Human BMSCs	17 miRNAs; hsa-miR-601, hsa-miR-452-3p, hsa-miR-647, and hsa-miR-516b-5p	5 miRNAs; hsa-miR-122-3p	[13]
5	Microarray qRT-PCR	Human and rat serum	15 miRNAs; miR-10a-5p, miR-99a-5p, miR-21-5p	12 miRNAs	[14, 15]
6	Microarray	Human serum	2 miRNAs	9 miRNAs	[16]
7	Microarray qRT-PCR	Human ONFH tissue	8 miRNAs	2 miRNAs; has-miR-195-5p	[17]
8	Microarray qRT-PCR	Human ONFH tissue	9 miRNAs; miR-210	19 miRNAs	[18]
9	Microarray qRT-PCR	Rat osteoblasts	4 miRNAs; miR-672-5p	2 miRNAs; miR-146a-5p	[19]
10	Microarray qRT-PCR	Human BMSCs	2 miRNAs; hsa-mir-483-5p, hsa-mir-708	6 miRNAs; hsa-mir-92a-1, hsa-mir-25	[20]
11	Microarray qRT-PCR	Rat BMSCs	9 upregulated; miR-27a	28 downregulated; miR-182	[21]
12	Microarray qRT-PCR	Human BMECs	5 up; hsa-miR-339-5p	11 down; hsa-miR-100-3p; hsa-miR-222-5p; hsa-miR-23b-5p; hsa-miR-933	[22]
13	Microarray qRT-PCR	Human serum	9 up; miR-423-5p	3 down; miR-10a-5p	[23]
14	Microarray qRT-PCR	Mice BMSCs	23 miRNAs; miR-21-3p miR-652-5p	16 miRNAs; miR-34b-3p,; miR-34c-5p,; miR-148a-3p,; miR-196a-5p,; miR-206-3p	[24]
15	Microarray qRT-PCR	Human BMSCs	11 miRNAs hsa-miR-4289 hsa-miR-378g hsa-miR-378f hsa-miR-378d hsa-miR-196b-5p hsa-miR-196a-5p hsa-miR-16-5p hsa-miR-1268b hsa-miR-1268a hsa-miR-107 hsa-miR-103a-3p	6 miRNAs; hsa-miR-4634 hsa-miR-4448 hsa-miR-378i hsa-miR-378h hsa-miR-378a-3p hsa-miR-24-3p	[25]

Note. miRNAs, microRNAs; ONFH, osteonecrosis of the femoral head; qRT-PCR, quantitative real-time polymerase chain reaction; BMSCs, bone marrow mesenchymal stem cells; BMECs, bone microvascular endothelial cells.