Review Article

Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head

Table 3

lncRNAs expression profiles in steroid-induced ONFH.

No.Evaluation methodSampleDysregulation (up)Dysregulation (down)References

1Microarray qRT-PCRHuman BMSCs181 lncRNAs391 lncRNAs
lncRNA RP11‐154D6
[5]

2Microarray qRT-PCRHuman ONFH tissue1179 lncRNAs
lncRNA NR 027293
3214 lncRNAs
lncRNAs ENST00000565178, NR 038891, T318776
[49]

3Microarray qRT-PCRHuman BMSCs1878 lncRNAs
OGFR-AS1, LOC100505817, HOTAIR, RP1-67K17.3, CTD-2006O16.2
1842 lncRNAs
RP1-193H18.2, XXBAC-BPGBPG55C20.3, MALAT1, CTD-3080F16.3, and RUNX1-IT1
[50]

4Microarray qRT-PCRHuman BMECs73 up
lncRNAp4493
166 down
lncRNAp19376
[22]

Note. lncRNAs, long noncoding RNAs; ONFH, osteonecrosis of the femoral head; qRT-PCR, quantitative real-time polymerase chain reaction; BMSCs, bone marrow mesenchymal stem cells; BMECs, bone microvascular endothelial cells.