Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head

Table 4

Functions of the lncRNAs in steroid-induced ONFH.

Evaluated lncRNA (s)	Study type	Involved cells	Target (s)	Pathway	Functions	Dysregulation (up/down)	Species	References
lncRNA RP11‐154D6	In vitro	BMSCs	—	—	Promote osteogenic differentiation and inhibit adipogenic differentiation	Down	Human	[5]
LncRNA EPIC1	In vitro	Osteoblasts	Myc (CDC20 and CCNA2)	—	Protect osteoblasts from steroid	Up	Human	[51]
Lnc-MALAT1	In vitro	Osteoblasts	Ppm1e	AMPK; Nrf2	Protect osteoblasts from steroid and attenuate oxidative stress	Down	Human	[52]

Note: LncRNAs, long noncoding RNAs; ONFH, osteonecrosis of the femoral head; BMSCs, bone marrow mesenchymal stem cells.