Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head

Table 5

Functions of the CircRNAs in steroid-induced ONFH.

Evaluated circRNA(s)	Study type	Involved cells/in vivo model	Target(s)	Pathway	Functions	Dysregulation (up/down)	Species	References
circHIPK3 (circ_0000284)	In vitro	Osteoblasts	miR-124	SphK1 and STAT3	Suppress steroid-induced apoptosis and programmed necrosis of osteoblasts	Down	Human	[6]
circUSP45	In vivo and in vitro	hBMSCs and rats	miR-127-5p	PTEN/AKT	Decrease osteogenic gene expression and inhibit the proliferation of hBMSCs	Up	Human and rat	[54]
cPWWP2A	In vitro	Osteoblasts	miR-579	SIRT1 and PDK1	Suppress steroid-induced apoptosis and programmed necrosis of osteoblasts	Down	Human	[55]

Note. CircRNAs, circular RNAs; ONFH, osteonecrosis of the femoral head; BMSCs, bone marrow mesenchymal stem cells.