HLA-DQB1/DRB1 Alleles Associate with Traditional Chinese Medicine Syndrome of Chronic Hepatitis B: A Potential Predictor of Progression

Table 2

Comparison of the frequencies of HLA-DQB1, HLA-DRB1 alleles between CHB group and control group.

Allele	Frequencies in CHB Group (2n = 148)	Frequencies in control Group (2n = 62)	OR (95% CI)	value
DQB102:01	12 (8.11%)	3 (4.84%)	1.78 (0.47–6.80)	0.55
DQB102:02	4 (2.70%)	3 (4.84%)	0.53 (0.11–2.54)	0.42
DQB103:01	29 (19.59%)	19 (30.65%)	0.41 (0.17–0.96)	0.04
DQB1 03:02	6 (4.05%)	3 (4.84%)	0.82 (0.19–3.53)	0.72
DQB103:03	35 (23.65%)	10 (14.52%)	2.19 (0.89–5.40)	0.08
DQB104:01	4 (2.70%)	0 (0.00%)	—	—
DQB105:01	3 (2.05%)	6 (9.68%)	0.46 (0.11–1.93)	0.38
DQB105:02	18 (12.16%)	4 (6.45%)	2.17 (0.67–7.04)	0.20
DQB105:03:01G	8 (5.41%)	5 (8.06%)	0.63 (0.19–2.11)	0.52
DQB106:01	18 (12.16%)	4 (6.45%)	2.17 (0.67–7.04)	0.19
DQB106:07	0 (0.00%)	1 (1.61%)	—	—
DQB106:10	1 (0.01%)	0 (0.00%)	—	—
DRB104:01	0 (0.00%)	1 (1.61%)	—	—
DRB104:05	4 (2.70%)	0 (0.00%)	—	—
DRB104:06	6 (4.05%)	2 (3.23%)	1.28 (0.24–6.72)	1
DRB112:01	2 (1.35%)	5 (8.06%)	0.14 (0.03–0.79)	0.02
DRB112:02	19 (12.84%)	7 (11.29k%)	1.18 (0.44–3.19)	0.81
DRB113:02	0 (0.00%)	1 (1.61%)	—	—
DRB113:12	2 (1.35%)	3 (4.84%)	0.26 (0.04–1.64)	0.15
DRB114:01:01G	10 (6.76%)	5 (8.06%)	0.81 (0.25–2.61)	0.76
DRB114:04	1 (0.68%)	1 (1.61%)	0.41 (0.03–6.79)	0.51
DRB114:05	3 (2.03%)	2 (3.23%)	0.61 (0.10–3.86)	0.63
DRB115:01	15 (10.14%)	5 (8.06%)	1.32 (0.44–4.02)	0.62
DRB115:02	0 (0.00%)	2 (3.23%)	—	—
DRB101:01	2 (1.35%)	1 (1.61%)	0.83 (0.07–9.54)	1
DRB103:01	12 (8.11%)	3 (4.84%)	1.81 (0.47–6.91)	0.54
DRB107:01	5 (3.38%)	3 (4.84%)	0.68 (0.15–3.02)	0.69
DRB108:03	15 (10.14%)	1 (1.61%)	7.63 (0.96–60.53)	0.04
DRB109:01	35 (23.65%)	10 (16.12%)	1.89 (0.78–4.55)	0.16
DRB110:01	1 (0.68%)	0 (0.00%)	—	—
DRB111:01	9 (6.08%)	4 (6.45%)	0.94 (0.27–3.30)	1

CHB, chronic hepatitis B. significant values (<0.05).