Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression

<div>DHA sensitized p53 (R248Q)-expressing cells to ADM. (a) Chemical structure of DHA. (b) Detection of cell viability upon DHA combined with ADM by MTT assay. (c) Representative image of colony formation. (d) Quantitative graph of colony number. (e) Detection of cell apoptosis by flow cytometry. (f) Quantitative graph of apoptotic rates. (g) Morphological changes of cells (magnification ×400). The red arrowhead indicated membrane invagination, nuclear condensation, and vacolation in apoptotic cells. 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BioMed Research International

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Figure 2

Figure 2: Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression 