Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells

Figure 1

Effect of SiNPs on the clonogenicity and EMT of BEAS-2B cells. (a) SiNPs were analyzed by electron microscope. (b) Cell viability at different concentrations of SiNPs. (c) Cell viability at different concentrations of BPDE. (d) Soft agar clonogenicity was assayed used BEAS-2B cells were treatment of BPDE without SiNPs (A) or with SiNPs (B). (e) Compared with the BPDE treated alone, the number of clones increased significantly after treatment of SiNPs (12.5 μg/mL). (f) Immunohistochemistry for EMT markers of BEAS-2B cells. p < 0.05.

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