Bioinformatic Analysis of Circular RNA-Associated ceRNA Network Associated with Hepatocellular Carcinoma

Table 4

TCGA analysis of key module genes.

Module gene	Hub gene (top 20)	Upregulate	Stage		Overall survival		Disease-free survival
			F value	value	HR	value	HR	value
VHL	Yes	–	2.4	0.0677	1.4	0.083	1.5	0.015
CDC26	No	–	2.4	0.04	1.5	0.025	1.6	0.0031
ANAPC11	No	Tumor	2.61	0.513	1.3	0.13	1.3	0.084
UBE2L3	Yes	Tumor	4.5	0.00409	1.8	0.0011	1.5	0.0077
SOCS3	Yes	Normal	0.651	0.583	1	0.92	0.95	0.72
NEDD8	Yes	Tumor	1.13	0.336	1.3	0.11	1.6	0.0041
UBE2G1	Yes	–	1.01	0.39	1.1	0.67	0.9	0.49
HECTD2	No	–	1.76	0.155	1.8	0.0011	1.5	0.0077