Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development

Table 4

Regression analysis (Studied SNP’s association with response Status (n=712, adjusted by Sex+Age+BMI).

SNPs	Model	Genotype	RA					OA
			Status=Cases	Status=Control	P-value	AIC	BIC	Status=; Cases	Status=; Control	P-value	AIC	BIC
rs10735810	Dominant	T/T	27 (9%)	397 (96.4%)	<0.0001	321.7	344.5	1 (0.3%)	397 (96.4%)	<0.0001	132.1	159.5
		C/T-C/C	273 (91%)	15 (3.6%)				309 (99.7%)	15 (3.6%)
	Recessive	T/T-C/T	139 (46.3%)	412 (100%)	<0.0001	611.4	634.3	204 (65.8%)	412 (100%)	<0.0001	702.8	730.3
		C/C	161 (53.7%)	0 (0%)				106 (34.2%)	0 (0%)
rs7975232	Dominant	T/T	12 (4%)	411 (99.8%)	<0.0001	123.3	146.1	6 (1.9%)	411 (99.8%)	<0.0001	52.7	80.2
		G/T-G/G	288 (96%)	1 (0.2%)				304 (98.1%)	1 (0.2%)
	Recessive	T/T-G/T	141 (47%)	412 (100%)	<0.0001	637	659.8	227 (73.2%)	412 (100%)	<0.0001	735.8	763.3
		G/G	159 (53%)	0 (0%)				83 (26.8%)	0 (0%)
rs1544410	Dominant	G/G	27 (9%)	412 (100%)	<0.0001	208.8	231.7	194 (62.6%)	412 (100%)	<0.0001	562.5	590
		A/G-A/A	273 (91%)	0 (0%)				116 (37.4%)	0 (0%)
	Recessive	G/G-A/G	91 (30.3%)	412 (100%)	<0.0001	484.6	507.5	79 (90%)	412 (100%)	<0.0001	771	798.5
		A/A	209 (69.7%)	0 (0%)				31 (10%)	0 (0%)
rs731236	Dominant	T/T	126 (42%)	412 (100%)	<0.0001	510.6	533.4	-	-	-	-	-
		A/T-A/A	174 (58%)	0 (0%)				-	-
	Recessive	T/T-A/T	285 (95%)	412 (100%)	<0.0001	947	969.8	-	-	-	-	-; -
		A/A	15 (5%)	0 (0%)				-	-

AIC=Akaike information criterion; BIC=Bayesian information criterion; P-value<0.01=significant.