Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development

Table 5

Haplotype Analysis of the VDR gene located on chromosome 12.

Haplotype: rs10735810; rs7975232; rs1544410; rs731236
Haplotype	RA; Frequency; (P/C)	p-value	Haplotype	OA; Frequency; (P/C)	p-value
CTGT	0.030/0.018	0.140	CTGT	0.015/0.018	0.651
TGGT	0.021/0.001	0.001	TGGT	0.004/0.001	0.001
TTGT	0.002/0.981	0.001	TTGT۞	0.000/0.981	0.016
CGAT	0.301/0.000	0.016	CGAT	0.102/0.000	0.016
CGGA	0.071/0.000	0.014	CGGA	0.088/0.000	0.015
CGGT	0.041/0.000	0.009	CGGT	0.379/0.000	0.016
CTAA	0.011/0.000	0.002	CTAA	0.001/0.000	>0.01
CTAT	0.188/0.000	0.016	CTGA	0.086/0.000	0.015
TGAA	0.120/0.000	0.015	TGAT	0.011/0.000	0.002
TGAT	0.102/0.000	0.015	TGGA	0.044/0.000	0.001
TGGA	0.007/0.000	0.001	TTAA	0.118/0.000	0.001
TTGA	0.026/0.000	0.006	TTGA	0.152/0.000	0.001

Represents a significant association of Haplotypes with Arthritis onset.
Represents a significant association of Haplotypes protective against Arthritis onset.