The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

Figure 2

Treatment with bosentan reduced atherosclerotic plaque formation in ApoE^−/− mice. (a) Hematoxylin-eosin staining of atherosclerotic plaques in bosentan-treated ApoE^−/− mice. T atherosclerotic plaques contained fewer foam cells and cholesterol crystals than those from untreated mice (magnification: 10X). (b) Enlarged sectional areas of plaques in the control, ApoE^−/−, and bosentan groups (magnification: 40X).

(a)

(b)